| http://purl.uniprot.org/citations/23395379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395379 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins involved in vesicle fusion during neurotransmitter release are well understood, whereas little is known about the protein machinery that mediates activity-dependent AMPA receptor (AMPAR) exocytosis during long-term potentiation (LTP). Using direct measurements of LTP in acute hippocampal slices and an in vitro LTP model of stimulated AMPAR exocytosis, we demonstrate that the Q-SNARE proteins syntaxin-3 and SNAP-47 are required for regulated AMPAR exocytosis during LTP but not for constitutive basal AMPAR exocytosis. In contrast, the R-SNARE protein synaptobrevin-2/VAMP2 contributes to both regulated and constitutive AMPAR exocytosis. Both the central complexin-binding and the N-terminal Munc18-binding sites of syntaxin-3 are essential for its postsynaptic role in LTP. Thus, postsynaptic exocytosis of AMPARs during LTP is mediated by a unique fusion machinery that is distinct from that used during presynaptic neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2012.11.029"xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Jurado S."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Goswami D."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Malenka R.C."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/author | "Molina A.J."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/pages | "542-558"xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/title | "LTP requires a unique postsynaptic SNARE fusion machinery."xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/23395379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23395379 |
| http://purl.uniprot.org/citations/23395379 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23395379 |
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