| http://purl.uniprot.org/citations/23395648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23395648 | http://www.w3.org/2000/01/rdf-schema#comment | "The heterodimeric transporter associated with antigen processing (TAP) gene loci is known to play a vital role in immune surveillance. We investigated a possible association of gene polymorphisms both in TAP1 and TAP2 in a cohort of clinically classified leprosy patients (n=222) and in ethnically matched controls (n=223). The TAP1 and TAP2 genes were genotyped for four single nucleotide polymorphisms TAP1 (rs1057141 Iso333Val and rs1135216 Asp637Gly) and TAP2 (rs2228396 Ala565Thr and rs241447 Ala665Thr) by direct sequencing and ARMS-PCR. The minor allele of TAP1 637G contributes to an increased risk to leprosy compared to controls (OR: 1.68, 95% CI 1.2-2.36, P=0.0057). An increased risk for the variant minor allele of the TAP1 637G to multibacillary (BL+LL) or paucibacillary (BT+TT) infections was also observed [multibacillary vs. controls (OR: 1.56, 95% CI 1.07-2.28, P=0.054); paucibacillary vs. controls (OR: 1.92, 95% CI 1.21-3.01, P=0.013)]. In the dominant model, the genotypes of the TAP1 rs1135216AG+GG additionally contributed to an increased risk. Overall our findings demonstrate that the TAP1 gene variant (rs1135216 Asp637Gly) influences the susceptibility to clinically classified leprosy patients in Indian population."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2013.01.001"xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Jain S."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Nath I."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Shinde V."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Valluri V.L."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Thangaraj K."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Rani D.S."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Arun S."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Velavan T.P."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Sunder S.R."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/author | "Marcinek P."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/pages | "803-807"xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/title | "Genetic evidence of TAP1 gene variant as a susceptibility factor in Indian leprosy patients."xsd:string |
| http://purl.uniprot.org/citations/23395648 | http://purl.uniprot.org/core/volume | "74"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A1V0E3X4-mappedCitation-23395648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23395648 |
| http://purl.uniprot.org/uniprot/#_A0A1V0E3X7-mappedCitation-23395648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23395648 |