| http://purl.uniprot.org/citations/23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23399893 | http://www.w3.org/2000/01/rdf-schema#comment | "Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (B-ALL), are driven by the oncogenic BCR-ABL fusion protein. Animal modeling experiments utilizing retroviral transduction and subsequent bone marrow transplantation have demonstrated that BCR-ABL generates both myeloid and lymphoid disease in mice receiving whole bone marrow transduced with BCR-ABL. Y177 of BCR-ABL is critical to the development of myeloid disease, and phosphorylation of Y177 has been shown to induce GRB2 binding to BCR-ABL, followed by activation of the Ras and phosphoinositide 3 kinase signaling pathways. We show that the GRB2-related adapter protein, GADS, also associates with BCR-ABL, specifically through Y177 and demonstrate that BCR-ABL-driven lymphoid disease requires Gads. BCR-ABL transduction of Gads(-/-) bone marrow results in short latency myeloid disease within 3-4 weeks of transplant, while wild-type mice succumb to both a longer latency lymphoid and myeloid diseases. We report that GADS mediates a unique BCR-ABL complex with SLP-76 in BCR-ABL-positive cell lines and B-ALL patient samples. These data suggest that GADS mediates lymphoid disease downstream of BCR-ABL through the recruitment of specific signaling intermediates."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2013.40"xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/author | "Barber D.L."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/author | "McGlade C.J."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/author | "Berry D.M."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/author | "Minden M.D."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/author | "Gillis L.C."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/pages | "1666-1676"xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/title | "Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia."xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23399893 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23399893 |
| http://purl.uniprot.org/citations/23399893 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23399893 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH91-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHI5-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_B7Z8E3-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_B7Z8F8-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_B7Z8J2-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_B7Z8M2-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_O75791-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_O89100-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_Q6FI14-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |
| http://purl.uniprot.org/uniprot/#_Q3U0E8-mappedCitation-23399893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23399893 |