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| Subject | Predicate | Object |
|---|---|---|
| http://purl.uniprot.org/citations/23401519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23401519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23401519 | http://www.w3.org/2000/01/rdf-schema#comment | "In many species where oocytes lack centrosomes, sperm contribute both genetic material and centriole(s) to the zygote. Correct centriole organization during male meiosis is critical to guarantee a normal bipolar mitotic spindle in the zygote. During Caenorhabditis elegans male meiosis, centrioles normally undergo two rounds of duplication, resulting in haploid sperm each containing a single tightly engaged centriole pair. Here we identify an unanticipated role for C. elegans HORMA (Hop1/Rev7/Mad2) domain proteins HTP-1/2 and HIM-3 in regulating centriole disengagement during spermatocyte meiosis. In him-3 and htp-1 htp-2 mutants, centrioles separate inappropriately during meiosis II, resulting in spermatids with disengaged centrioles. Moreover, extra centrosomes are detected in a subset of zygotes. Together, these data implicate HIM-3 and HTP-1/2 in preventing centriole disengagement during meiosis II. We showed previously that HTP-1/2 prevents premature loss of sister chromatid cohesion during the meiotic divisions by inhibiting removal of meiotic cohesin complexes containing the REC-8 subunit. Worms lacking REC-8, or expressing a mutant separase protein with elevated local concentration at centrosomes and in sperm, likewise exhibit inappropriate centriole separation during spermatocyte meiosis. These observations are consistent with HIM-3 and HTP-1/2 preventing centriole disengagement by inhibiting separase-dependent cohesin removal. Our data suggest that the same specialized meiotic mechanisms that function to prevent premature release of sister chromatid cohesion during meiosis I in C. elegans also function to inhibit centriole separation at meiosis II, thereby ensuring that the zygote inherits the appropriate complement of chromosomes and centrioles."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1213888110"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1213888110"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Bembenek J.N."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Bembenek J.N."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Villeneuve A.M."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Villeneuve A.M."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Schvarzstein M."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Schvarzstein M."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Pattabiraman D."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/author | "Pattabiraman D."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/pages | "E898-E907"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/pages | "E898-E907"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/title | "Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/title | "Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis."xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23401519 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23401519 |
| http://purl.uniprot.org/citations/23401519 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23401519 |