| http://purl.uniprot.org/citations/23401610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23401610 | http://www.w3.org/2000/01/rdf-schema#comment | "Complexins (Cplxs) are small, SNARE-associated proteins believed to regulate fast, calcium-triggered exocytosis. However, studies have pointed to either an inhibitory and/or facilitatory role in exocytosis, and the role of Cplxs in synchronizing exocytosis is relatively unexplored. Here, we compare the function of two types of complexin, Cplx 1 and 2, in two model systems of calcium-dependent exocytosis. In mouse neuromuscular junctions (NMJs), we find that lack of Cplx 1 significantly reduces and desynchronizes calcium-triggered synaptic transmission; furthermore, high-frequency stimulation elicits synaptic facilitation, instead of normal synaptic depression, and the degree of facilitation is highly sensitive to the amount of cytoplasmic calcium buffering. In Cplx 2-null adrenal chromaffin cells, we also find decreased and desynchronized evoked release, and identify a significant reduction in the vesicle pool close to the calcium channels (immediately releasable pool, IRP). Viral transduction with either Cplx 1 or 2 rescues both the size of the evoked response and the synchronicity of release, and it restores the IRP size. Our findings in two model systems are mutually compatible and indicate a role of Cplx 1 and 2 in facilitating vesicle priming, and also lead to the new hypothesis that Cplxs may synchronize vesicle release by promoting coupling between secretory vesicles and calcium channels."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.org/dc/terms/identifier | "doi:10.1113/jphysiol.2012.244517"xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Cai H."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Lin M.Y."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Reim K."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Chow R.H."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Ko C.P."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/author | "Rohan J.G."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/name | "J Physiol"xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/pages | "2463-2473"xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/title | "Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems."xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://purl.uniprot.org/core/volume | "591"xsd:string |
| http://purl.uniprot.org/citations/23401610 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23401610 |
| http://purl.uniprot.org/citations/23401610 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23401610 |
| http://purl.uniprot.org/uniprot/#_D3YZ72-mappedCitation-23401610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23401610 |
| http://purl.uniprot.org/uniprot/#_P63040-mappedCitation-23401610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23401610 |
| http://purl.uniprot.org/uniprot/#_P84086-mappedCitation-23401610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23401610 |
| http://purl.uniprot.org/uniprot/P63040 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23401610 |
| http://purl.uniprot.org/uniprot/D3YZ72 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23401610 |
| http://purl.uniprot.org/uniprot/P84086 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23401610 |