| http://purl.uniprot.org/citations/23410103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23410103 | http://www.w3.org/2000/01/rdf-schema#comment | "The importance of the complex interrelated regulatory pathways involving IGF factors and pancreatic hormones can be observed in several metabolic diseases, where the deregulation of these factors has a wide impact on bone health. These findings have stimulated us to compare the effect of IGF-I, IGF-II, insulin and preptin on human bone cells. The effect on cell differentiation and cell activity of osteoblasts and osteoclasts has been analysed. We have observed a significant effect by IGF-I, a modest effect by IGF-II and preptin and no effect after insulin administration on human primary osteoblast-like cells. All studied factors have shown an induction on human primary osteoclast differentiation and bone resorption activity, with IGF-I being the most potent factor. We hypothesize that these findings may be on the basis of decreased bone mass density observed in several diseases."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.org/dc/terms/identifier | "doi:10.3109/08977194.2013.770392"xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/author | "Fusaro L."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/author | "Bosetti M."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/author | "Cannas M."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/author | "Sabbatini M."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/author | "Nicoli E."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/pages | "57-65"xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/title | "Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells."xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/23410103 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23410103 |
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