| http://purl.uniprot.org/citations/23412975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23412975 | http://www.w3.org/2000/01/rdf-schema#comment | "Valosin-containing protein (VCP), or p97, is a member of the ATP-binding protein family, and is involved in numerous cellular events, such as, protein degradation, membrane fusion, and chaperone activity. VCP has been demonstrated playing a critical role in non-small-cell lung cancer (NSCLC) pathogenesis and progression recently. We investigated the association between VCP polymorphisms and clinical outcome in advanced NSCLC patients undergoing platinum-based chemotherapy. We recruited 663 Chinese advanced NSCLC patients who were treated with platinum-based regimens, and using their clinical data, we assessed the efficacy and side effects of their treatment. Three tag-single nucleotide polymorphisms (SNPs) of VCP were genotyped. SNP rs2074549 showed a significant association with severe neutropenia. Its G/G genotype increased the risk of grade 3 or 4 neutropenia compared with wild-type homozygotes A/A (P = .001, odds ratio = 2.975). Haplotype association analysis revealed that CGA was associated with the increased incidence of severe neutropenia (P = .041, odds ratio = 1.439). However, no significant relationship was found between the presence of VCP polymorphisms and treatment efficacy when objective response, progression-free survival, and overall survival (OS) were evaluated. Our study is the first to provide evidence that VCP polymorphisms are associated with a severe chemotherapy-related adverse outcome in platinum-treated advanced NSCLC patients."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-012-0631-9"xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Chen H.Y."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Wang H.J."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Gao Z.Q."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Wang J.C."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Zhao X.Y."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Qian J."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Yang L.X."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Wang W.M."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Han B.H."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Bai C.X."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Wu W.T."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/author | "Lu D.R."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/pages | "953-961"xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/title | "VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23412975 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23412975 |
| http://purl.uniprot.org/citations/23412975 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23412975 |