| http://purl.uniprot.org/citations/23413029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23413029 | http://www.w3.org/2000/01/rdf-schema#comment | "Prolyl hydroxylase domain protein 2 (PHD2, also known as Egg Laying Defective Nine homolog 1) is a key oxygen-sensing protein in metazoans. In an oxygen-dependent manner, PHD2 site-specifically prolyl hydroxylates the master transcription factor of the hypoxic response, hypoxia-inducible factor-α (HIF-α), thereby targeting HIF-α for degradation. In this report we show that the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif (where Xaa = any amino acid) in these proteins with the N-terminal Myeloid Nervy and DEAF-1 (MYND)-type zinc finger of PHD2. Knockdown of p23 augments hypoxia-induced HIF-1α protein levels and HIF target genes. We propose that p23 recruits PHD2 to the HSP90 machinery to facilitate HIF-1α hydroxylation. These findings identify a link between two ancient pathways, the PHD:HIF and the HSP90 pathways, and suggest that this link was established concurrent with the emergence of the PHD:HIF pathway in evolution."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.440552"xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Song D."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Lee F.S."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Li L.S."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Arsenault P.R."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Heaton-Johnson K.J."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/author | "Master S.R."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/pages | "9662-9674"xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/title | "Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway."xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23413029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23413029 |
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