Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/23413430http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23413430http://www.w3.org/2000/01/rdf-schema#comment"

Objective

One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening.

Approach and results

Obese (ob/ob) mice were used to examine physical, morphological, and molecular changes in the aorta in response to obesity. ob/ob mice had increased aortic pulse wave velocity and tissue rigidity. ob/ob aorta exhibited decreases of lysyl oxidase (LOX) activity and cross-linked elastin, and increases of elastin fragmentation and elastolytic activity. The aortas of ob/ob mice were surrounded by a significant amount of proinflammatory and pro-oxidative perivascular adipose tissue. In vitro studies revealed that the conditioned medium from differentiated adipocytes or the perivascular adipose tissue of ob/ob mice attenuated LOX activity. Furthermore, inhibition of LOX in wild-type lean mice caused elastin fragmentation and induced a significant increase in pulse wave velocity. Finally, we found that obese humans had stiffer arteries and lower serum LOX levels than do normal-weight humans.

Conclusions

Our results demonstrated that obesity resulted in aortic stiffening in both humans and mice, and established a causal relationship between LOX downregulation and aortic stiffening in obesity."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.112.300036"xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Chang Y.T."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Chen J.Y."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Li Y.H."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tsai Y.S."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Wang M.C."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Wu H.L."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Lin L.J."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tsai W.C."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Chou C.H."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tang M.J."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Chiou Y.W."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tsai P.J."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tai H.C."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Tsai R.L."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Yeh M.L."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Shiesh S.C."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/author"Lam C.F."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/pages"839-846"xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/title"Increased aortic stiffness and attenuated lysyl oxidase activity in obesity."xsd:string
http://purl.uniprot.org/citations/23413430http://purl.uniprot.org/core/volume"33"xsd:string
▶