| http://purl.uniprot.org/citations/23418361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23418361 | http://www.w3.org/2000/01/rdf-schema#comment | "The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function. The melanocortin receptor accessory protein (MRAP) and its paralogue MRAP2 are small single-pass transmembrane proteins that have been shown to regulate MCR expression and function. In the adrenal gland, MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor. The importance of MRAP in adrenal gland physiology is demonstrated by the clinical condition familial glucocorticoid deficiency, where inactivating MRAP mutations account for ∼20% of cases. MRAP is highly expressed in both the zona fasciculata and the undifferentiated zone. Expression in the undifferentiated zone suggests that MRAP could also be important in adrenal cell differentiation and/or maintenance. In contrast, the role of adrenal MRAP2, which is highly expressed in the foetal gland, is unclear. The expression of MRAPs outside the adrenal gland is suggestive of a wider physiological purpose, beyond MC2R-mediated adrenal steroidogenesis. In vitro, MRAPs have been shown to reduce surface expression and signalling of all the other MCRs (MC1,3,4,5R). MRAP2 is predominantly expressed in the hypothalamus, a site that also expresses a high level of MC3R and MC4R. This raises the intriguing possibility of a CNS role for the MRAPs."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.org/dc/terms/identifier | "doi:10.1530/joe-12-0501"xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/author | "Clark A.J."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/author | "Jackson D."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/author | "Chan L.F."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/author | "Novoselova T.V."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/author | "Campbell D.C."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/name | "J Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/pages | "R1-11"xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/title | "Melanocortin receptor accessory proteins in adrenal gland physiology and beyond."xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://purl.uniprot.org/core/volume | "217"xsd:string |
| http://purl.uniprot.org/citations/23418361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23418361 |
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