| http://purl.uniprot.org/citations/23420539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23420539 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies on the role of the tetraspanin CD37 in cellular immunity appear contradictory. In vitro approaches indicate a negative regulatory role, whereas in vivo studies suggest that CD37 is necessary for optimal cellular responses. To resolve this discrepancy, we studied the adaptive cellular immune responses of CD37(-/-) mice to intradermal challenge with either tumors or model antigens and found that CD37 is essential for optimal cell-mediated immunity. We provide evidence that an increased susceptibility to tumors observed in CD37(-/-) mice coincides with a striking failure to induce antigen-specific IFN-γ-secreting T cells. We also show that CD37 ablation impairs several aspects of DC function including: in vivo migration from skin to draining lymph nodes; chemo-tactic migration; integrin-mediated adhesion under flow; the ability to spread and form actin protrusions and in vivo priming of adoptively transferred naïve T cells. In addition, multiphoton microscopy-based assessment of dermal DC migration demonstrated a reduced rate of migration and increased randomness of DC migration in CD37(-/-) mice. Together, these studies are consistent with a model in which the cellular defect that underlies poor cellular immune induction in CD37(-/-) mice is impaired DC migration."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201242730"xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Hickey M.J."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Wright M.D."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Chang T.M."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Wee J.L."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "van Spriel A.B."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Apostolopoulos V."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Pietersz G.A."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Jones E.L."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Gartlan K.H."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Nastovska R."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/author | "Demaria M.C."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/pages | "1208-1219"xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/title | "Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration."xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/23420539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23420539 |
| http://purl.uniprot.org/citations/23420539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23420539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS72-mappedCitation-23420539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSS0-mappedCitation-23420539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GST6-mappedCitation-23420539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420539 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSZ7-mappedCitation-23420539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420539 |