| http://purl.uniprot.org/citations/23420875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23420875 | http://www.w3.org/2000/01/rdf-schema#comment | "Obscurin is a large myofibrillar protein that contains several interacting modules, one of which mediates binding to muscle-specific ankyrins. Interaction between obscurin and the muscle-specific ankyrin sAnk1.5 regulates the organization of the sarcoplasmic reticulum in striated muscles. Additional muscle-specific ankyrin isoforms, ankB and ankG, are localized at the subsarcolemma level, at which they contribute to the organization of dystrophin and β-dystroglycan at costameres. In this paper, we report that in mice deficient for obscurin, ankB was displaced from its localization at the M band, whereas localization of ankG at the Z disk was not affected. In obscurin KO mice, localization at costameres of dystrophin, but not of β-dystroglycan, was altered, and the subsarcolemma microtubule cytoskeleton was disrupted. In addition, these mutant mice displayed marked sarcolemmal fragility and reduced muscle exercise tolerance. Altogether, the results support a model in which obscurin, by targeting ankB at the M band, contributes to the organization of subsarcolemma microtubules, localization of dystrophin at costameres, and maintenance of sarcolemmal integrity."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201205118"xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Lange S."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Sorrentino V."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Giacomello E."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Rossi D."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Blaauw B."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Pierantozzi E."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Reggiani C."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Randazzo D."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Lorenzini S."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/author | "Peter A.K."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/pages | "523-536"xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/title | "Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity."xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/23420875 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23420875 |
| http://purl.uniprot.org/citations/23420875 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23420875 |
| http://purl.uniprot.org/uniprot/#_A0A571BEB2-mappedCitation-23420875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420875 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6H1-mappedCitation-23420875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420875 |
| http://purl.uniprot.org/uniprot/#_A2AAJ9-mappedCitation-23420875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420875 |
| http://purl.uniprot.org/uniprot/#_E9QQ96-mappedCitation-23420875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23420875 |