| http://purl.uniprot.org/citations/23422957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23422957 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DC) are required for priming antigen-specific T cells and acquired immunity to many important human pathogens, including Mycobacteriuim tuberculosis (TB) and influenza. However, inappropriate priming of auto-reactive T cells is linked with autoimmune disease. Understanding the molecular mechanisms that regulate the priming and activation of naïve T cells is critical for development of new improved vaccines and understanding the pathogenesis of autoimmune diseases. The serine/threonine kinase IKKα (CHUK) has previously been shown to have anti-inflammatory activity and inhibit innate immunity. Here, we show that IKKα is required in DC for priming antigen-specific T cells and acquired immunity to the human pathogen Listeria monocytogenes. We describe a new role for IKKα in regulation of IRF3 activity and the functional maturation of DC. This presents a unique role for IKKα in dampening inflammation while simultaneously promoting adaptive immunity that could have important implications for the development of new vaccine adjuvants and treatment of autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.28"xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Fong C."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Chi H."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Johnson E."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Memet S."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Lawrence T."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Seed M."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Bebien M."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Caamano J."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Bajenoff M."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Luron L."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Mancino A."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/author | "Habbeddine M."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/pages | "816-828"xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/title | "I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection."xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23422957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23422957 |
| http://purl.uniprot.org/citations/23422957 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23422957 |
| http://purl.uniprot.org/uniprot/#_A0A140LHC2-mappedCitation-23422957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23422957 |