| http://purl.uniprot.org/citations/23426181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23426181 | http://www.w3.org/2000/01/rdf-schema#comment | "Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction, but the mechanisms underlying increased mortality are unknown. Mice with streptozotocin-induced diabetes developed profound heart rate slowing and doubled mortality compared with controls after myocardial infarction. Oxidized Ca(2+)/calmodulin-dependent protein kinase II (ox-CaMKII) was significantly increased in pacemaker tissues from diabetic patients compared with that in nondiabetic patients after myocardial infarction. Streptozotocin-treated mice had increased pacemaker cell ox-CaMKII and apoptosis, which were further enhanced by myocardial infarction. We developed a knockin mouse model of oxidation-resistant CaMKIIδ (MM-VV), the isoform associated with cardiovascular disease. Streptozotocin-treated MM-VV mice and WT mice infused with MitoTEMPO, a mitochondrial targeted antioxidant, expressed significantly less ox-CaMKII, exhibited increased pacemaker cell survival, maintained normal heart rates, and were resistant to diabetes-attributable mortality after myocardial infarction. Our findings suggest that activation of a mitochondrial/ox-CaMKII pathway contributes to increased sudden death in diabetic patients after myocardial infarction."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci65268"xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Gao Z."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Lang D."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Luo M."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Guan X."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Glynn P."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Anderson M.E."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Weiss R.M."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Hund T.J."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Luczak E.D."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Sossalla S."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Maier L.S."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Efimov I.R."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Kutschke W."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Rokita A.G."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/author | "Swaminathan P.D."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/pages | "1262-1274"xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/title | "Diabetes increases mortality after myocardial infarction by oxidizing CaMKII."xsd:string |
| http://purl.uniprot.org/citations/23426181 | http://purl.uniprot.org/core/volume | "123"xsd:string |