| http://purl.uniprot.org/citations/23426969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23426969 | http://www.w3.org/2000/01/rdf-schema#comment | "This study was designed to test a hypothesis that the functional activity of big-conductance, Ca(2+)-activated K(+) (BK) channels is different in cerebral and pulmonary artery smooth muscle cells (CASMCs and PASMCs). Using patch-clamp recordings, we found that the activity of whole cell and single BK channels were significantly higher in CASMCs than in PASMCs. The voltage and Ca(2+) sensitivity of BK channels were greater in CASMCs than in PASMCs. Targeted gene knockout of β(1)-subunits significantly reduced BK currents in CASMCs but had no effect in PASMCs. Western blotting experiments revealed that BK channel α-subunit protein expression level was comparable in CASMCs and PASMCs; however, β(1)-subunit protein expression level was higher in CASMCs than in PASMCs. Inhibition of BK channels by the specific blocker iberiotoxin enhanced norepinephrine-induced increase in intracellular calcium concentration in CASMCs but not in PASMCs. Systemic artery blood pressure was elevated in β(1)(-/-) mice. In contrast, pulmonary artery blood pressure was normal in β(1)(-/-) mice. These findings provide the first evidence that the activity of BK channels is higher in cerebral than in PASMCs. This heterogeneity is primarily determined by the differential β(1)-subunit function and contributes to diverse cellular responses in these two distinct types of cells."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00006.2012"xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Wang Y.X."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Tang Q."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Park S.W."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Zheng Y.M."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Stokes L."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/author | "Xiao J.H."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/pages | "C780-9"xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/title | "Distinct activity of BK channel beta1-subunit in cerebral and pulmonary artery smooth muscle cells."xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://purl.uniprot.org/core/volume | "304"xsd:string |
| http://purl.uniprot.org/citations/23426969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23426969 |
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