| http://purl.uniprot.org/citations/23428435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23428435 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingomyelin phosphodiesterase 3 (Smpd3) encodes a membrane-bound enzyme that cleaves sphingomyelin to generate several bioactive metabolites. A recessive mutation called fragilitas ossium (fro) in the Smpd3 gene leads to impaired mineralization of bone and tooth extracellular matrix (ECM) in fro/fro mice. In teeth from fro/fro mice at various neonatal ages, radiography and light and electron microscopy showed delayed mantle dentin mineralization and a consequent delay in enamel formation as compared with that in control +/fro mice. These tooth abnormalities progressively improved with time. Immunohistochemistry showed expression of SMPD3 by dentin-forming odontoblasts. SMPD3 deficiency, however, did not affect the differentiation of these cells, as shown by osterix and dentin sialophosphoprotein expression. Using a transgenic mouse rescue model (fro/fro; Col1a1-Smpd3) in which Smpd3 expression is driven by a murine Col1a1 promoter fragment active in osteoblasts and odontoblasts, we demonstrate a complete correction of the tooth mineralization delays. In conclusion, analysis of these data demonstrates that Smpd3 expression in odontoblasts is required for tooth mineralization."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.org/dc/terms/identifier | "doi:10.1177/0022034513478429"xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "McKee M.D."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "Murshed M."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "Khavandgar Z."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "Alebrahim S."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "Eimar H."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/author | "Tamimi F."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/name | "J Dent Res"xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/pages | "358-364"xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/title | "Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3."xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/23428435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23428435 |
| http://purl.uniprot.org/citations/23428435 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23428435 |
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| http://purl.uniprot.org/uniprot/#_Q9JJY3-mappedCitation-23428435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23428435 |
| http://purl.uniprot.org/uniprot/Q3US57 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23428435 |
| http://purl.uniprot.org/uniprot/Q9JJY3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23428435 |