| http://purl.uniprot.org/citations/23429371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23429371 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain tumors are one of the most common childhood malignancies. Diffuse high-grade gliomas represent approximately 10% of pediatric brain tumors. Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these mutations can be considered specific for pediatric diffuse high-grade astrocytomas or also occur in other pediatric brain tumors. We performed a pyrosequencing-based analysis for the identification of H3F3A codon 27 and codon 34 mutations in 338 pediatric brain tumors. The K27M mutation occurred in 35 of 129 glioblastomas (27.1%) and in 5 of 28 (17.9%) anaplastic astrocytomas. None of the other tumor entities showed H3F3A K27M mutation. Because H3F3A K27M mutations occur exclusively in pediatric diffuse high-grade astrocytomas, analysis of codon 27 mutational status could be useful in the differential diagnosis of these neoplasms."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.org/dc/terms/identifier | "doi:10.1309/ajcpabohbc33fvmo"xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Waha A."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Pietsch T."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Kramm C.M."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Gessi M."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Hammes J."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/author | "Gielen G.H."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/name | "Am J Clin Pathol"xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/pages | "345-349"xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/title | "H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas."xsd:string |
| http://purl.uniprot.org/citations/23429371 | http://purl.uniprot.org/core/volume | "139"xsd:string |
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