http://purl.uniprot.org/citations/23431138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23431138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23431138 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/BCL2 protein. Here we report a major alternative mechanism for caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of apoptosis."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1217271110"xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1217271110"xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Campo E."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Campo E."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Ceribelli M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Ceribelli M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Chan W.C."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Chan W.C."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Chiorazzi M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Chiorazzi M."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Delabie J."xsd:string |
http://purl.uniprot.org/citations/23431138 | http://purl.uniprot.org/core/author | "Delabie J."xsd:string |