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http://purl.uniprot.org/citations/23434585http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23434585http://www.w3.org/2000/01/rdf-schema#comment"The STAT3 transcription factor plays a central role in a wide range of cancer types where it is over-expressed. Previously, phosphorylation of this protein was thought to be a prerequisite for direct binding to DNA. However, we have now shown complete binding of a purified unphosphorylated STAT3 (uSTAT3) core directly to M67 DNA, the high affinity STAT3 target DNA sequence, by a protein electrophoretic mobility shift assay (PEMSA). Binding to M67 DNA was inhibited by addition of increasing concentrations of a phosphotyrosyl peptide. X-ray crystallography demonstrates one mode of binding that is similar to that known for the STAT3 core phosphorylated at Y705."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2013.01.065"xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Shah R."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Wilderspin A.F."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Bui T.T."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Drake A.F."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Palmer J."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Parkinson G.N."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Neidle S."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Zinzalla G."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Rahman K.M."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Thurston D.E."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Collie G.W."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Husby J."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/author"Nkansah E."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/pages"833-839"xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/title"Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography."xsd:string
http://purl.uniprot.org/citations/23434585http://purl.uniprot.org/core/volume"587"xsd:string
http://purl.uniprot.org/citations/23434585http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23434585
http://purl.uniprot.org/citations/23434585http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23434585
http://purl.uniprot.org/uniprot/P42227#attribution-0611A7674C4A239D7595B0203C4C4C31http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/23434585
http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-23434585http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23434585