| http://purl.uniprot.org/citations/23443048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23443048 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocytes use the integrin leukocyte function-associated antigen-1 (LFA-1) to cross the vasculature into lymph nodes (LNs), but it has been uncertain whether their migration within LN is also LFA-1 dependent. We show that LFA-1 mediates prolonged LN residence as LFA-1(-/-) CD4 T cells have significantly decreased dwell times compared with LFA-1(+/+) T cells, a distinction lost in hosts lacking the major LFA-1 ligand ICAM-1. Intra-vital two-photon microscopy revealed that LFA-1(+/+) and LFA-1(-/-) T cells reacted differently when probing the ICAM-1-expressing lymphatic network. While LFA-1(+/+) T cells returned to the LN parenchyma with greater frequency, LFA-1(-/-) T cells egressed promptly. This difference in exit behaviour was a feature of egress through all assessed lymphatic exit sites. We show that use of LFA-1 as an adhesion receptor amplifies the number of T cells returning to the LN parenchyma that can lead to increased effectiveness of T-cell response to antigen. Thus, we identify a novel function for LFA-1 in guiding T cells at the critical point of LN egress when they either exit or return into the LN for further interactions."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.33"xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Jones K."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Hogg N."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Patzak I."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Gunzer M."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Reichardt P."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/author | "Etemire E."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/pages | "829-843"xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/title | "A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes."xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/23443048 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23443048 |
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