| http://purl.uniprot.org/citations/23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23447676 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkin and DJ-1 are two multi-functional proteins linked to autosomal recessive early-onset Parkinson's disease (PD) that have been shown to functionally interact by as-yet-unknown mechanisms. We have delineated the mechanisms by which parkin controls DJ-1. Parkin modulates DJ-1 transcription and protein levels via a signaling cascade involving p53 and the endoplasmic reticulum (ER)-stress-induced active X-box-binding protein-1S (XBP-1S). Parkin triggers the transcriptional repression of p53 while p53 downregulates DJ-1 protein and mRNA expressions. We show that parkin-mediated control of DJ-1 is fully p53-dependent. Furthermore, we establish that p53 lowers the protein and mRNA levels of XBP-1S. Accordingly, we show that parkin ultimately upregulates XBP-1 levels. Subsequently, XBP-1S physically interacts with the DJ-1 promoter, thereby enhancing its promoter trans-activation, mRNA levels and protein expression. This data was corroborated by the examination of DJ-1 in both parkin- and p53-null mice brains. This transcriptional cascade is abolished by pathogenic parkin mutations and is independent of its ubiquitin-ligase activity. Our data establish a parkin-dependent ER-stress-associated modulation of DJ-1 and identifies p53 and XBP-1 as two major actors acting downstream of parkin in this signaling cascade in cells and in vivo. This work provides a mechanistic explanation for the increase in the unfolded protein response observed in PD pathology, i.e. that it is due to a defect in parkin-associated control of DJ-1."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.127340"xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Brice A."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Checler F."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Sevalle J."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Corti O."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Duplan E."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Giaime E."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Alves da Costa C."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/author | "Viotti J."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/pages | "2124-2133"xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/title | "ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1."xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/23447676 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23447676 |
| http://purl.uniprot.org/citations/23447676 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23447676 |
| http://purl.uniprot.org/uniprot/#_A0A087WQJ2-mappedCitation-23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23447676 |
| http://purl.uniprot.org/uniprot/#_D3JZW5-mappedCitation-23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23447676 |
| http://purl.uniprot.org/uniprot/#_D3K2X1-mappedCitation-23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23447676 |
| http://purl.uniprot.org/uniprot/#_D3K2X2-mappedCitation-23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23447676 |
| http://purl.uniprot.org/uniprot/#_D3K2X3-mappedCitation-23447676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23447676 |