| http://purl.uniprot.org/citations/23448979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23448979 | http://www.w3.org/2000/01/rdf-schema#comment | "Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding partner, and its overexpression has been shown in different human cancers. Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, we performed a conformational analysis of the h-Prune C-terminal to identify the amino acids involved in the interaction with Nm23-H1. We developed a competitive permeable peptide (CPP) to impair the formation of the Nm23-H1/h-Prune complex and demonstrated that CPP causes impairment of cell motility, substantial impairment of tumor growth and metastases formation. Meta-analysis performed on three Neuroblastoma cohorts showed Nm23-H1 as the gene highly associated to Neuroblastoma aggressiveness. We also identified two other proteins (PTPRA and TRIM22) with expression levels significantly affected by CPP. These data suggest a new avenue for potential clinical application of CPP in Neuroblastoma treatment."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep01351"xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Schramm A."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Navas L."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Zollo M."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Arrigoni G."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Westermann F."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Pirone L."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Basso G."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Monti S.M."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Saviano M."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Pedone E."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Carotenuto M."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Bruder E."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Correale S."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Fattorusso R."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Schulte J.H."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Ponzoni M."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Cimmino F."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Marino N."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Dzeroski S."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Zenko B."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Eggert A."xsd:string |
| http://purl.uniprot.org/citations/23448979 | http://purl.uniprot.org/core/author | "Accordi B."xsd:string |