| http://purl.uniprot.org/citations/23449193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23449193 | http://www.w3.org/2000/01/rdf-schema#comment | "Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acute effects of intragastric (IG) infusion of a small molecule diacylglycerol acyltransferase-1 inhibitor (DGAT-1i) on eating, circulating fat metabolites, indirect calorimetry, and hepatic and intestinal expression of key fat catabolism enzymes in male rats adapted to an 8 h feeding-16 h deprivation schedule. Also, the DGAT-1i effect on fatty acid oxidation (FAO) was investigated in enterocyte cell culture models. IG DGAT-1i infusions reduced energy intake compared with vehicle in high-fat diet (HFD)-fed rats, but scarcely in chow-fed rats. IG DGAT-1i also blunted the postprandial increase in serum TAG and increased β-hydroxybutyrate levels only in HFD-fed rats, in which it lowered the respiratory quotient and increased intestinal, but not hepatic, protein levels of Complex III of the mitochondrial respiratory chain and of mitochondrial hydroxymethylglutaryl-CoA synthase. Finally, the DGAT-1i enhanced FAO in CaCo2 (EC50 = 0.3494) and HuTu80 (EC50 = 0.00762) cells. Thus, pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available. This may contribute to the observed eating-inhibitory effect."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m035154"xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Arnold M."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Schober G."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Mansouri A."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Langhans W."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Turnbull A.V."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Birtles S."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Buckett L.K."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/author | "Pacheco-Lopez G."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/pages | "1369-1384"xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/title | "Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats."xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/23449193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23449193 |
| http://purl.uniprot.org/citations/23449193 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23449193 |
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| http://purl.uniprot.org/uniprot/#_Q793I4-mappedCitation-23449193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23449193 |
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| http://purl.uniprot.org/uniprot/#_Q9ERM3-mappedCitation-23449193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23449193 |