| http://purl.uniprot.org/citations/23452853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23452853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23452853 | http://www.w3.org/2000/01/rdf-schema#comment | "Endosomal protein trafficking is an essential cellular process that is deregulated in several diseases and targeted by pathogens. Here, we describe a role for ubiquitination in this process. We find that the E3 RING ubiquitin ligase, MAGE-L2-TRIM27, localizes to endosomes through interactions with the retromer complex. Knockdown of MAGE-L2-TRIM27 or the Ube2O E2 ubiquitin-conjugating enzyme significantly impaired retromer-mediated transport. We further demonstrate that MAGE-L2-TRIM27 ubiquitin ligase activity is required for nucleation of endosomal F-actin by the WASH regulatory complex, a known regulator of retromer-mediated transport. Mechanistic studies showed that MAGE-L2-TRIM27 facilitates K63-linked ubiquitination of WASH K220. Significantly, disruption of WASH ubiquitination impaired endosomal F-actin nucleation and retromer-dependent transport. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.01.051"xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.01.051"xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Chen Z.J."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Doyle J.M."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Doyle J.M."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Jia D."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Jia D."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Ramanathan S."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Ramanathan S."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Potts P.R."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Potts P.R."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Hao Y.H."xsd:string |
| http://purl.uniprot.org/citations/23452853 | http://purl.uniprot.org/core/author | "Hao Y.H."xsd:string |