| http://purl.uniprot.org/citations/23453807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23453807 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkin, a RING-between-RING-type E3 ubiquitin ligase associated with Parkinson's disease, has a wide neuroprotective activity, preventing cell death in various stress paradigms. We identified a stress-protective pathway regulated by parkin that links NF-κB signaling and mitochondrial integrity via linear ubiquitination. Under cellular stress, parkin is recruited to the linear ubiquitin assembly complex and increases linear ubiquitination of NF-κB essential modulator (NEMO), which is essential for canonical NF-κB signaling. As a result, the mitochondrial guanosine triphosphatase OPA1 is transcriptionally upregulated via NF-κB-responsive promoter elements for maintenance of mitochondrial integrity and protection from stress-induced cell death. Parkin-induced stress protection is lost in the absence of either NEMO or OPA1, but not in cells defective for the mitophagy pathway. Notably, in parkin-deficient cells linear ubiquitination of NEMO, activation of NF-κB, and upregulation of OPA1 are significantly reduced in response to TNF-α stimulation, supporting the physiological relevance of parkin in regulating this antiapoptotic pathway."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.01.036"xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Winklhofer K.F."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Schweimer C."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Kuhn P.H."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Lichtenthaler S.F."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Wurst W."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Langer T."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Hadian K."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Krappmann D."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Trumbach D."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Dittmar G."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Patra M."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Tatzelt J."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Motori E."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Muller-Rischart A.K."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Pilsl A."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Hrelia S."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Funke M."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Deinlein A."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Beaudette P."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/author | "Peis R."xsd:string |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23453807 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |