| http://purl.uniprot.org/citations/23454274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23454274 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-translational modification of proteins by deamidation or transamidation by tissue transglutaminase (tTG) has been suggested as a possible mechanism for the development of autoimmunity. Sequence analysis of protein kinase C delta (PKCδ) identified an amino acid motif that suggested the possibility that PKCδ was a glutamine substrate of tTG and MALDI-TOF analysis of synthesised peptides from PKCδ proved that this was the case. Polymerisation experiments using recombinant tTG and biotinylated hexapeptide substrate incorporation assays demonstrated that PKCδ is a substrate for tTG-mediated transamidation. Elevated levels of anti-PKCδ antibodies were detected in sera from patients with coeliac disease (p<0.0001) but not from patients with other autoimmune disorders. These data suggest that a subset of patients with coeliac disease produce autoantibodies against PKCδ and that this response may stem from a tTG-PKCδ substrate interaction."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2013.01.007"xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/author | "Whelan A."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/author | "Feighery C."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/author | "Byrne G."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/author | "Freeley M."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/title | "Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease."xsd:string |
| http://purl.uniprot.org/citations/23454274 | http://purl.uniprot.org/core/volume | "147"xsd:string |
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