Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/23463341http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23463341http://www.w3.org/2000/01/rdf-schema#comment"

Background

Urinary tract infections (UTIs) are encountered frequently in children, and their early diagnosis and treatment are important. This study evaluates the diagnostic value of serum concentrations of lipopolysaccharide-binding protein (LBP), an acute-phase protein, in children with febrile UTI and compares it to those of the total white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6).

Methods

The study population comprised 77 consecutive patients with a first-episode febrile UTI (33 boys) with a median age of 11 months [interquartile range (IQR), 5.5-33 months], 21 healthy controls (11 boys) with a median age of 10 months (IQR, 5-20.5 months) and 58 febrile controls with a fever due to other causes (28 boys) with a median age of 12.5 months (IQR, 7-30 months). LBP, IL-6, PCT, and CRP were measured for both patients and control groups.

Results

The serum levels of LBP (p  < 0.001), CRP (p  <  0.001), PCT (p  =  0.001), IL-6 (p  =  0.002), ESR (p  = 0.020), and WBC (p  <  0.001) were higher in patients with febrile UTI than in the healthy and febrile control groups. The LPB cut-off value for best sensitivity and specificity in patients with febrile UTI was >43.23 mg/l. Furthermore, the area under the receiver operating characteristic curve was significantly greater for LBP than for CRP (p  =  0.014), PCT (p  <  0.001), ESR (p  <  0.001), WBC (p  =  0.002) and IL-6 (p  =  0.006).

Conclusions

The results of this study suggest that the serum LBP concentration constitutes a reliable biologic marker for the diagnosis of a febrile UTI in children."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.org/dc/terms/identifier"doi:10.1007/s00467-013-2432-9"xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Chatzimichael A."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Roilides E."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Kortsaris A."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Trypsianis G."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Tentes I."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Gardikis S."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/author"Tsalkidou E.A."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/name"Pediatr Nephrol"xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/pages"1091-1097"xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/title"Lipopolysaccharide-binding protein: a potential marker of febrile urinary tract infection in childhood."xsd:string
http://purl.uniprot.org/citations/23463341http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/23463341http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23463341
http://purl.uniprot.org/citations/23463341http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23463341
http://purl.uniprot.org/uniprot/#_P18428-mappedCitation-23463341http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23463341
http://purl.uniprot.org/uniprot/#_Q8TCF0-mappedCitation-23463341http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23463341
http://purl.uniprot.org/uniprot/P18428http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23463341
http://purl.uniprot.org/uniprot/Q8TCF0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23463341