| http://purl.uniprot.org/citations/23466604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23466604 | http://www.w3.org/2000/01/rdf-schema#comment | "A new class of serotonin 5-HT1A receptor ligands related to NAN-190, buspirone and aripiprazole has been designed using our potent 5-HT3 receptor ligands as templates. The designed pyrrolidone derivatives 10a-n were prepared by means of the straightforward chemistry consisting in the reaction of the appropriate γ-haloester derivatives with the suitable arylpiperazinylalkylamines. The nanomolar 5-HT1A receptor affinity and the agonist-like profile shown by fused pyrrolidone derivatives 10k,m stimulated the rationalization of the interaction with an homology model of the 5-HT1A receptor and the evaluation of their selectivity profiles and the pharmacokinetic properties. Interestingly, the results of the profiling assays suggested for close congeners 10k,m a significantly divergent binding pattern with compound 10m showing an appreciable selectivity for 5-HT1AR."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejmech.2013.01.044"xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Lanza M."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Giorgi G."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Campiani G."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Caselli G."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Giordani A."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Brogi S."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Butini S."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Gemma S."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Cappelli A."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Valenti S."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Anzini M."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Makovec F."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Mennuni L."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Giuliani G."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Castriconi F."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Letari O."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/author | "Manini M."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/name | "Eur J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/pages | "85-94"xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/title | "Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds."xsd:string |
| http://purl.uniprot.org/citations/23466604 | http://purl.uniprot.org/core/volume | "63"xsd:string |