| http://purl.uniprot.org/citations/23468876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23468876 | http://www.w3.org/2000/01/rdf-schema#comment | "Maternal hyperglycemia can inhibit morphogenesis of ureteric bud branching, Glial cell line-derived neurotrophilic factor (GDNF) is a key regulator of the initiation of ureteric branching. Early growth response gene-1 (EGR-1) is an immediate early gene. Preliminary study found EGR-1 persistently expressed with GDNF in hyperglycemic environment. To evaluate the potential relationship of hyperglycemia-GDNF-EGR-1 pathway, in vitro human renal proximal tubular epithelial (HRPTE) cells as target and in vivo streptozotocin-induced mice model were used. Our in vivo microarray, real time-PCR and confocal morphological observation confirmed apoptosis in hyperglycemia-induced fetal nephropathy via activation of the GDNF/MAPK/EGR-1 pathway at E12-E15. Detachment between ureteric branch and metanephrons, coupled with decreasing number and collapse of nephrons on Day 1 newborn mice indicate hyperglycemic environment suppress ureteric bud to invade metanephric rudiment. In vitro evidence proved that high glucose suppressed HRPTE cell migration and enhanced GDNF-EGR-1 pathway, inducing HRPTE cell apoptosis. Knockdown of EGR-1 by siRNA negated hyperglycemic suppressed GDNF-induced HRPTE cells. EGR-1 siRNA also reduced GDNF/EGR-1-induced cRaf/MEK/ERK phosphorylation by 80%. Our findings reveal a novel mechanism of GDNF/MAPK/EGR-1 activation playing a critical role in HRPTE cell migration, apoptosis and fetal hyperglycemic nephropathy."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0056731"xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/author | "Lin T.Y."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/author | "Lee M.C."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/author | "Chen S.C."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/pages | "e56731"xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/title | "Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy."xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23468876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23468876 |
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