| http://purl.uniprot.org/citations/23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23468968 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem cell populations are maintained through self-renewing divisions in which one daughter cell commits to a specific fate while the other retains the multipotent characteristics of its parent. The p53 tumor suppressor, in conjunction with its interacting partner protein Numb, preserves this asymmetry and functions as a vital barrier against the unchecked expansion of tumor stem cell pools; however, little is known about the biological control of the Numb-p53 interaction. We show here that Numb and p53 are the constituents of a high molecular mass complex, which is disintegrated upon activation of aPKCζ, a Numb kinase. Using large-scale affinity purification and tandem mass spectrometry, we identify TBC1D15 as a Numb-associated protein and demonstrate that its amino-terminal domain disengages p53 from Numb, triggering p53 proteolysis and promoting self-renewal and pluripotency. Cellular levels of TBC1D15 are diminished upon acute nutrient deprivation through autophagy-mediated degradation, indicating that TBC1D15 serves as a conduit through which cellular metabolic status is linked to self-renewal. The profound deregulation of TBC1D15 expression exhibited in a diverse array of patient tumors underscores its proposed function as an oncoprotein."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0057312"xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/author | "Feldman D.E."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/author | "Machida K."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/author | "Punj V."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/pages | "e57312"xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/title | "The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex."xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23468968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23468968 |
| http://purl.uniprot.org/citations/23468968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23468968 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_A5JTV6-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_Q925E2-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_Q05BE7-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_O70366-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |
| http://purl.uniprot.org/uniprot/#_Q80ZA1-mappedCitation-23468968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23468968 |