| http://purl.uniprot.org/citations/23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23472002 | http://www.w3.org/2000/01/rdf-schema#comment | "G protein-coupled receptor (GPR) 55 is sensitive to certain cannabinoids, it is expressed in the brain and, in cell cultures, it triggers mobilization of intracellular Ca(2+). However, the adaptive neurobiological significance of GPR55 remains unknown. Here, we use acute hippocampal slices and combine two-photon excitation Ca(2+) imaging in presynaptic axonal boutons with optical quantal analysis in postsynaptic dendritic spines to find that GPR55 activation transiently increases release probability at individual CA3-CA1 synapses. The underlying mechanism involves Ca(2+) release from presynaptic Ca(2+) stores, whereas postsynaptic stores (activated by spot-uncaging of inositol 1,4,5-trisphosphate) remain unaffected by GPR55 agonists. These effects are abolished by genetic deletion of GPR55 or by the GPR55 antagonist cannabidiol, a constituent of Cannabis sativa. GPR55 shows colocalization with synaptic vesicle protein vesicular glutamate transporter 1 in stratum radiatum. Short-term potentiation of CA3-CA1 transmission after a short train of stimuli reveals a presynaptic, Ca(2+) store-dependent component sensitive to cannabidiol. The underlying cascade involves synthesis of phospholipids, likely in the presynaptic cell, but not the endocannabinoids 2-arachidonoylglycerol or anandamide. Our results thus unveil a signaling role for GPR55 in synaptic circuits of the brain."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1211204110"xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/author | "Ross R.A."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/author | "Jensen T.P."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/author | "Rusakov D.A."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/author | "Sylantyev S."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/pages | "5193-5198"xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/title | "Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses."xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23472002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23472002 |
| http://purl.uniprot.org/citations/23472002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23472002 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y6K3-mappedCitation-23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/#_F1MAK4-mappedCitation-23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23472002 |
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| http://purl.uniprot.org/uniprot/#_Q14BW0-mappedCitation-23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/#_Q3UJF0-mappedCitation-23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/#_Q9WU09-mappedCitation-23472002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/Q9WU09 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/Q3UJF0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23472002 |
| http://purl.uniprot.org/uniprot/A0A8I5Y6K3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23472002 |
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| http://purl.uniprot.org/uniprot/Q14BV9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23472002 |