| http://purl.uniprot.org/citations/23474333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23474333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23474333 | http://www.w3.org/2000/01/rdf-schema#comment | "The nasopharyngeal pathogen Moraxella catarrhalis recruits vitronectin to subvert complement-mediated killing. Ubiquitous surface protein (UspA) 2 and its hybrid form UspA2H bind vitronectin at the highly diverse N-terminal head domain. Here we characterized the sequence diversity of the head domain in multiple M. catarrhalis clinical isolates (n = 51) with focus on binding of vitronectin. The head domain of the uspA2 genes from 40 isolates were clustered according to an N-terminal sequence motif of UspA2 (NTER2), i.e., NTER2A (55% of uspA2 variants), NTER2B (32.5%), NTER2C (5%), and finally a group without an NTER2 (7.5%). Isolates harbouring the uspA2H gene (n = 11) contained N-terminal GGG repeats. Vitronectin binding to isolates having UspA2 did not correlate to variation in the NTER2 motifs but occurred in UspA2H containing 6 or ≥11 of GGG repeats. Analyses of recombinant UspA2/UspA2H head domains of multiple variants showed UspA2-dependent binding to the C-terminal of vitronectin. Furthermore, polyclonal anti-UspA2 antibodies revealed that the head domain of the majority of Moraxella UspA2/2H was antigenically unrelated, whereas the full length molecules were recognized. In conclusion, the head domains of UspA2/2H have extensive sequence polymorphism without losing vitronectin-binding capacity promoting a general evasion of the host immune system."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micinf.2013.02.004"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Singh B."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Singh B."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Su Y.C."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Su Y.C."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Riesbeck K."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Riesbeck K."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Bernhard S."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Bernhard S."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Hallstrom B.M."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/author | "Hallstrom B.M."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/name | "Microbes Infect."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/name | "Microbes Infect"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/pages | "375-387"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/pages | "375-387"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/title | "Impact of sequence diversity in the Moraxella catarrhalis UspA2/UspA2H head domain on vitronectin binding and antigenic variation."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/title | "Impact of sequence diversity in the Moraxella catarrhalis UspA2/UspA2H head domain on vitronectin binding and antigenic variation."xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/23474333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23474333 |