| http://purl.uniprot.org/citations/23474901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23474901 | http://www.w3.org/2000/01/rdf-schema#comment | "A series of (coumarin-3-yl)carbamates was synthesized and evaluated in vitro as monoamine oxidase (MAO-A and MAO-B) inhibitors. Most of the new compounds selectively inhibited MAO-B isoenzyme with IC50 values in the micro or nanoMolar ranges. Since these compounds must achieve the brain cells, theoretical evaluation of ADME properties were also carried out. Compound 8 (benzyl(coumarin-3-yl)carbamate), which presented the most interesting in vitro MAO-B inhibitory profile (IC50 against MAO-B = 45 nM), was subjected to further studies. This in vitro MAO-B inhibitory activity is comparable with that of the selegiline, the reference compound (IC50 against MAO-B = 20 nM). Taking into account the in vitro results of compound 8, in vivo assays and docking calculations were also carried out for this derivative."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejmech.2013.02.009"xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Friedman C."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Uriarte E."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Tatonetti N.P."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Fontenla J.A."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Gonzalez-Franco R.M."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Matos M.J."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Santana L."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Vilar S."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/author | "Vina D."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/name | "Eur J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/pages | "151-161"xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/title | "Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study."xsd:string |
| http://purl.uniprot.org/citations/23474901 | http://purl.uniprot.org/core/volume | "63"xsd:string |
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| http://purl.uniprot.org/uniprot/P27338 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23474901 |
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