| http://purl.uniprot.org/citations/23479569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23479569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23479569 | http://www.w3.org/2000/01/rdf-schema#comment | "IL1RAP, a co-receptor for interleukin (IL)-1 and IL-33 receptors, was previously found to be highly upregulated on candidate chronic myeloid leukemia stem cells, allowing for leukemia-selective killing using IL1RAP-targeting antibodies. We analyzed IL1RAP expression in a consecutive series of 29 patients with acute myeloid leukemia (AML) and, based on the level of expression in mononuclear cells (MNCs), we divided the samples into 3 groups: IL1RAP low (n = 6), IL1RAP intermediate (n = 11), and IL1RAP high (n = 12). Within the CD34+CD38-population, the intermediate and high groups expressed higher levels of IL1RAP than did corresponding normal cells. With the aim to target AML stem cells, an anti-IL1RAP monoclonal antibody was generated followed by isotype switching for improved antibody-dependent, cell-mediated cytotoxicity activity. Using this antibody, we achieved selective killing of AML MNC, CD34+CD38+, and CD34+CD38-cells. Our findings demonstrate that IL1RAP is a promising new therapeutic target in AML."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-09-458935"xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-09-458935"xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Richter J."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Richter J."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Gordon S."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Gordon S."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Hansen N."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Hansen N."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Rissler M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Rissler M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Fioretos T."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Fioretos T."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Aagerstam H."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Aagerstam H."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Arvanitakis A."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Arvanitakis A."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Askmyr M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Askmyr M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Jaeraas M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Jaeraas M."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Juliusson G."xsd:string |
| http://purl.uniprot.org/citations/23479569 | http://purl.uniprot.org/core/author | "Juliusson G."xsd:string |