| http://purl.uniprot.org/citations/23483710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23483710 | http://www.w3.org/2000/01/rdf-schema#comment | "The insulin/insulin-like growth factor-1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain-of-function mutations in p110α, the principal mammalian IIS-responsive isoform of PI 3-kinase (PI3K), promote cancer. In contrast, loss-of-function mutations in p110α impair insulin signalling and cause insulin resistance, inducing a pre-diabetic state. It remains unknown if long-term p110α inactivation induces further metabolic deterioration over time, leading to overt unsustainable pathology. Surprisingly, we find that chronic p110α partial inactivation in mice protects from age-related reduction in insulin sensitivity, glucose tolerance and fat accumulation, and extends the lifespan of male mice. This beneficial effect of p110α inactivation derives in part from a suppressed down-regulation of insulin receptor substrate (IRS) protein levels induced by age-related hyperinsulinemia, and correlates with enhanced insulin-induced Akt signalling in aged p110α-deficient mice. This temporal metabolic plasticity upon p110α inactivation indicates that prolonged PI3K inhibition, as intended in human cancer treatment, might not negatively impact on organismal metabolism."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.org/dc/terms/identifier | "doi:10.1002/emmm.201201953"xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Ali K."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Pearce W."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Withers D.J."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Foukas L.C."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Vanhaesebroeck B."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Sancho S."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Bilanges B."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/author | "Bettedi L."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/name | "EMBO Mol Med"xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/pages | "563-571"xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/title | "Long-term p110alpha PI3K inactivation exerts a beneficial effect on metabolism."xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/23483710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23483710 |
| http://purl.uniprot.org/citations/23483710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23483710 |
| http://purl.uniprot.org/uniprot/#_D3YY41-mappedCitation-23483710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23483710 |
| http://purl.uniprot.org/uniprot/#_P42337-mappedCitation-23483710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23483710 |
| http://purl.uniprot.org/uniprot/P42337 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23483710 |
| http://purl.uniprot.org/uniprot/D3YY41 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23483710 |