| http://purl.uniprot.org/citations/23485564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23485564 | http://www.w3.org/2000/01/rdf-schema#comment | "Efficient clearance of apoptotic cells by phagocytes is important for development, tissue homeostasis, and the prevention of autoimmune responses. Phagosomes containing apoptotic cells undergo acidification and mature from Rab5-positive early to Rab7-positive late stages. Phagosomes finally fuse with lysosomes to form phagolysosomes, which degrade apoptotic cells; however, the molecular mechanism underlying phagosome-lysosome fusion is not fully understood. Here we show that the Caenorhabditis elegans Arf-like small GTPase Arl8 (ARL-8) is involved in phagolysosome formation and is required for the efficient removal of apoptotic cells. Loss of function of arl-8 results in the accumulation of apoptotic germ cells. Both the engulfment of the apoptotic cells by surrounding somatic sheath cells and the phagosomal maturation from RAB-5-to RAB-7-positive stages occur in arl-8 mutants. However, the phagosomes fail to fuse with lysosomes in the arl-8 mutants, leading to the accumulation of RAB-7-positive phagosomes and the delayed degradation of apoptotic cells. ARL-8 localizes primarily to lysosomes and physically interacts with the homotypic fusion and protein sorting complex component VPS-41. Collectively our findings reveal that ARL-8 facilitates apoptotic cell removal in vivo by mediating phagosome-lysosome fusion during phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e12-08-0628"xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Gengyo-Ando K."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Sasaki A."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Abe F."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Nagasawa M."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Katada T."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Kontani K."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Fukuyama M."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/author | "Nakae I."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/pages | "1584-1592"xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/title | "Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23485564 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23485564 |
| http://purl.uniprot.org/citations/23485564 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23485564 |
| http://purl.uniprot.org/uniprot/#_G5EDC6-mappedCitation-23485564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23485564 |
| http://purl.uniprot.org/uniprot/#_Q19954-mappedCitation-23485564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23485564 |
| http://purl.uniprot.org/uniprot/#_Q23145-mappedCitation-23485564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23485564 |
| http://purl.uniprot.org/uniprot/#_Q23146-mappedCitation-23485564 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23485564 |