| http://purl.uniprot.org/citations/23487425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23487425 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinase-8 (MMP-8) is a potent interstitial collagenase thought to be expressed mainly by polymorphonuclear neutrophils. To determine whether MMP-8 regulates lung inflammatory or fibrotic responses to bleomycin, we delivered bleomycin by the intratracheal route to wild-type (WT) versus Mmp-8(-/-) mice and quantified MMP-8 expression, and inflammation and fibrosis in the lung samples. Mmp-8 steady state mRNA and protein levels increase in whole lung and bronchoalveolar lavage samples when WT mice are treated with bleomycin. Activated murine lung fibroblasts express Mmp-8 in vitro. MMP-8 expression is increased in leukocytes in the lungs of patients with idiopathic pulmonary fibrosis compared with control lung samples. Compared with bleomycin-treated WT mice, bleomycin-treated Mmp-8(-/-) mice have greater lung inflammation, but reduced lung fibrosis. Whereas bleomycin-treated Mmp-8(-/-) and WT mice have similar lung levels of several pro- and antifibrotic mediators (TGF-β, IL-13, JE, and IFN-γ), Mmp-8(-/-) mice have higher lung levels of IFN-γ-inducible protein-10 (IP-10) and MIP-1α. Genetically deleting either Ip-10 or Mip-1α in Mmp-8(-/-) mice abrogates their lung inflammatory response to bleomycin, but reconstitutes their lung fibrotic response to bleomycin. Studies of bleomycin-treated Mmp-8 bone marrow chimeric mice show that both leukocytes and lung parenchymal cells are sources of profibrotic MMP-8 during bleomycin-mediated lung fibrosis. Thus, during bleomycin-mediated lung injury, MMP-8 dampens the lung acute inflammatory response, but promotes lung fibrosis by reducing lung levels of IP-10 and MIP-1α. These data indicate therapeutic strategies to reduce lung levels of MMP-8 may limit fibroproliferative responses to injury in the human lung."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1201043"xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Kobzik L."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Craig V.J."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Owen C.A."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Patel A.S."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Fyfe S.E."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Quintero P.A."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/author | "Knolle M.D."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/pages | "4283-4296"xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/title | "Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury."xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://purl.uniprot.org/core/volume | "190"xsd:string |
| http://purl.uniprot.org/citations/23487425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23487425 |
| http://purl.uniprot.org/citations/23487425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23487425 |
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