| http://purl.uniprot.org/citations/23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23490419 | http://www.w3.org/2000/01/rdf-schema#comment | "Oral lichen planus (OLP) is a T cell-mediated autoimmune disease of oral mucosa, in which T helper 1 (Th1) cells are greatly involved. Chemokine CCL5 is required for T cells infiltration and activation. CCR5, one of its receptors, specifically expressed on Th1 cells among CD4(+) T cells, can be up-regulated by Th1 cytokines like interleukin2 (IL-2) and interferon-gamma (IFN-γ), and down-regulated by Th2 cytokines like IL-4. The present study aimed to determine whether CCL5 and CCR5 had effects on the immune response of OLP. We analyzed the proportion of CCR5(+)CD4(+) T cells in CD4(+) T cells using flow cytometry and the serum levels of CCL5, IL-2, IFN-γ, and IL-4 with ELISA. MicroRNA-125a (miR-125a), a blocker of CCL5, was examined with RT-PCR. The results showed both the serum CCL5 and the percentage of CCR5(+)CD4(+) T cells elevated in OLP patients. Serum IL-2 and IFN-γ increased in OLP patients, but IL-4 decreased. MiR-125a was down-regulated in OLP patients, and there was a negative correlation between miR-125a content and the OLP severity which was measured with a RAE (reticular, atrophic and erosive lesion) scoring system. In conclusion, increasing CCl5/CCR5 might participate in the immune response of OLP. Th1-type cytokines environment presented in OLP probably performed as a magnifier for the CCR5. Moreover, miR-125a might be a candidate biomarker to estimate the severity of OLP."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2013.01.020"xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Lu R."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Zhou G."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Hu J.Y."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Xu X.Y."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Liang X.Y."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Cui J.L."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/author | "Du G.F."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/pages | "141-145"xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/title | "Increasing CCL5/CCR5 on CD4+ T cells in peripheral blood of oral lichen planus."xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/23490419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23490419 |
| http://purl.uniprot.org/citations/23490419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-23490419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23490419 |