| http://purl.uniprot.org/citations/23492732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23492732 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms that maintain podocytes and consequently, the integrity of the glomerular filtration barrier are incompletely understood. Here, we show that the class III phosphoinositide 3-kinase vacuolar protein sorting 34 (Vps34) plays a central role in modulating endocytic pathways, maintaining podocyte homeostasis. In mice, podocyte-specific conditional knockout of Vps34 led to early proteinuria, glomerular scarring, and death within 3-9 weeks of age. Vps34-deficient podocytes exhibited substantial vacuolization and foot process effacement. Although the formation of autophagosomes and autophagic flux were impaired, comparisons between podocyte-specific Vps34-deficient mice, autophagy-deficient mice, and doubly deficient mice suggested that defective autophagy was not primarily responsible for the severe phenotype caused by the loss of Vps34. In fact, Rab5-positive endosomal compartments, endocytosis, and fluid-phase uptake were severely disrupted in Vps34-deficient podocytes. Vps34 deficiency in nephrocytes, the podocyte-like cells of Drosophila melanogaster, resulted in a block between Rab5- and Rab7-positive endosomal compartments. In summary, these data identify Vps34 as a major regulator of endolysosomal pathways in podocytes and underline the fundamental roles of endocytosis and fluid-phase uptake for the maintenance of the glomerular filtration barrier."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2012070700"xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Walz G."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Kerjaschki D."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Helmstadter M."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Huber T.B."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Schell C."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Kretz O."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Hartleben B."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Kiefer B."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Bechtel W."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Balica J."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Geist F."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/author | "Hrnjic F."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/pages | "727-743"xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/title | "Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23492732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23492732 |
| http://purl.uniprot.org/citations/23492732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23492732 |
| http://purl.uniprot.org/uniprot/#_A0A385JBX3-mappedCitation-23492732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23492732 |
| http://purl.uniprot.org/uniprot/#_E9Q824-mappedCitation-23492732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23492732 |