| http://purl.uniprot.org/citations/23493396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23493396 | http://www.w3.org/2000/01/rdf-schema#comment | "Cerebral malaria (CM) is a severe clinical complication of Plasmodium falciparum malaria infection and is characterized by a high fatality rate and neurological damage. Sequestration of parasite-infected red blood cells in brain microvasculature utilizes host- and parasite-derived adhesion molecules and is an important factor in the development of CM. ICAM-1, an alternatively spliced adhesion molecule, is believed to be critical on endothelial cells for infected red blood cell sequestration in CM. Using ICAM-1 mutant mice, we found that the full-length ICAM-1 isoform is not required for development of murine experimental CM (ECM) and that ECM phenotype varies with the combination of ICAM-1 isoforms expressed. Furthermore, we observed development of ECM in transgenic mice expressing ICAM-1 only on leukocytes, indicating that endothelial cell expression of this adhesion molecule is not required for disease pathogenesis. We propose that ICAM-1-dependent cellular aggregation, independent of ICAM-1 expression on the cerebral microvasculature, contributes to ECM."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c113.457028"xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "Barnum S.R."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "McDonald K."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "Crawford D.F."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "Bullard D.C."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "Ramos T.N."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/author | "Darley M.M."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/pages | "10962-10966"xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/title | "Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (icam-1)."xsd:string |
| http://purl.uniprot.org/citations/23493396 | http://purl.uniprot.org/core/volume | "288"xsd:string |
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