| http://purl.uniprot.org/citations/23495688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23495688 | http://www.w3.org/2000/01/rdf-schema#comment | "The lysosomal serine carboxypeptidase CatA has a very important and well-known structural function as well as a, so far, less explored catalytic function. A complete loss of the CatA protein results in the lysosomal storage disease galactosialidosis caused by intralysosomal degradation of β-galactosidase and neuraminidase 1. However, mice with a catalytically inactive CatA enzyme show no signs of this disease. This observation establishes a clear distinction between structural and catalytic functions of the CatA enzyme. Recently, several classes of orally bioavailable synthetic inhibitors of CatA have been identified. Pharmacological studies in rodents indicate a remarkable influence of CatA inhibition on cardiovascular disease progression and identify CatA as a promising novel target for the treatment of heart failure."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.org/dc/terms/identifier | "doi:10.4155/fmc.13.24"xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Wirth K."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Ruf S."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Schreuder H."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Ruetten H."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Sadowski T."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Hubschle T."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Linz W."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Buning C."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/author | "Linz D."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/name | "Future Med Chem"xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/pages | "399-409"xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/title | "Inhibition of CatA: an emerging strategy for the treatment of heart failure."xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/23495688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23495688 |
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