| http://purl.uniprot.org/citations/23498137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23498137 | http://www.w3.org/2000/01/rdf-schema#comment | "IGFBP-3 is a tumor suppressor whose expression is frequently suppressed in lung cancer. NNK, the most potent tobacco carcinogen, enhanced cell proliferation of BEAS-2B normal lung epithelial cells and concomitantly suppressed IGFBP-3 expression through DNA methylation. Decreased IGFBP-3 expression and elevated levels of phospho-Akt, phospho-p65-NF-κB, and cyclin D1 were detected in tobacco carcinogen-induced tumorigenic derivatives of BEAS-2B. Overexpression of IGFBP-3 in NNKA, one of the derivatives, suppressed NF-κB activity and induced apoptosis, which was hindered by knocking-down of endogenous IGFBP-3R, an IGFBP-3 specific receptor. These results suggest that NNK inhibits IGFBP-3 expression to abrogate anti-tumor actions of the IGFBP-3/IGFBP-3R system in smoking-induced lung cancer."xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.lungcan.2013.02.016"xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/author | "Harada A."xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/author | "Oh Y."xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/author | "Jogie-Brahim S."xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/name | "Lung Cancer"xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/pages | "270-277"xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/title | "Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone suppresses a newly identified anti-tumor IGFBP-3/IGFBP-3R system in lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23498137 | http://purl.uniprot.org/core/volume | "80"xsd:string |
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