| http://purl.uniprot.org/citations/23499019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23499019 | http://www.w3.org/2000/01/rdf-schema#comment | "Acetyl-coenzyme A (acetyl-CoA) carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the regulated step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase (BC), biotinylated biotin carboxyl carrier protein (BCCP), and an α2β2 heterotetrameric carboxyltransferase. This enzyme complex catalyzes two half-reactions to form malonyl-coenzyme A. BC and BCCP participate in the first half-reaction, whereas carboxyltransferase and BCCP are involved in the second. Three-dimensional structures have been reported for the individual subunits; however, the structural basis for how BCCP reacts with the carboxylase or transferase is unknown. Therefore, we report here the crystal structure of E. coli BCCP complexed with BC to a resolution of 2.49 Å. The protein-protein complex shows a unique quaternary structure and two distinct interfaces for each BCCP monomer. These BCCP binding sites are unique compared to phylogenetically related biotin-dependent carboxylases and therefore provide novel targets for developing antibiotics against bacterial acetyl-CoA carboxylase."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2013.02.001"xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Broussard T.C."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Neau D.B."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Pakhomova S."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Waldrop G.L."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Kobe M.J."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Price A.E."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/author | "Champion T.S."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/pages | "650-657"xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/title | "The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA carboxylase."xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/23499019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23499019 |
| http://purl.uniprot.org/citations/23499019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23499019 |
| http://purl.uniprot.org/uniprot/P0ABD8#attribution-1A3641394AC17CAA9045080593876E53 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23499019 |
| http://purl.uniprot.org/uniprot/#_P24182-mappedCitation-23499019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499019 |
| http://purl.uniprot.org/uniprot/#_P0ABD8-mappedCitation-23499019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499019 |
| http://purl.uniprot.org/uniprot/P24182 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23499019 |
| http://purl.uniprot.org/uniprot/P0ABD8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23499019 |