| http://purl.uniprot.org/citations/23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23499423 | http://www.w3.org/2000/01/rdf-schema#comment | "The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specific characteristics. Here, we show that early B cell factor-2 (Ebf2) regulates Pparγ binding activity to determine brown versus white adipocyte identity. The Ebf DNA-binding motif was highly enriched within brown adipose-specific Pparγ binding sites that we identified by genome-wide ChIP-Seq. Of the Ebf isoforms, Ebf2 was selectively expressed in brown relative to white adipocytes and was bound at brown adipose-specific Pparγ target genes. When expressed in myoblasts or white preadipose cells, Ebf2 recruited Pparγ to its brown-selective binding sites and reprogrammed cells to a brown fat fate. Brown adipose cells and tissue from Ebf2-deficient mice displayed a loss of brown-specific characteristics and thermogenic capacity. Together, these results identify Ebf2 as a key transcriptional regulator of brown fat cell fate and function."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2013.01.015"xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Ishibashi J."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Reed R.R."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Rajakumari S."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Seale P."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Lim H.W."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Won K.J."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/author | "Giang A.H."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/pages | "562-574"xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/title | "EBF2 determines and maintains brown adipocyte identity."xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/23499423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23499423 |
| http://purl.uniprot.org/citations/23499423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23499423 |
| http://purl.uniprot.org/uniprot/O08792#attribution-0ED154AE62339BFD5DAABA01F99EA6D8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/O08792#attribution-4EF54ECB52AB97D5C61F299FD63AA55C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/#_D3Z7M4-mappedCitation-23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU17-mappedCitation-23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499423 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF8-mappedCitation-23499423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499423 |