| http://purl.uniprot.org/citations/23499463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23499463 | http://www.w3.org/2000/01/rdf-schema#comment | "Much fewer mice lacking androgen receptor (AR) in the entire body develop bladder cancer (BCa). However, the role of urothelial AR (Uro-AR) in BCa development remains unclear. In the present study, we generated mice that lacked only Uro-AR (Uro-AR(-/y)) to develop BCa by using the carcinogen BBN [N-butyl-N-(4-hydroxybutyl)-nitrosamine] and found that Uro-AR(-/y) mice had a lower incidence of BCa and a higher survival rate than did their wild-type (WT; Uro-AR(+/y)) littermates. In vitro assay also demonstrated that Uro-AR facilitates the neoplastic transformation of normal urothelial cells to carcinoma. IHC staining exhibited less DNA damage, with much higher expression of p53 and its downstream target protein PNCA in Uro-AR(-/y) than that found in WT urothelium, which suggests that Uro-AR may modulate bladder tumorigenesis through p53-PCNA DNA repair signaling. Indeed, Uro-AR(-/y) mice with the transgene, simian vacuolating virus 40 T (SV40T), in the urothelium (Uro-SV40T-AR(-/y)) had a similar incidence of BCa as did their WT littermates (Uro-SV40T-AR(+/y)), and p53 was inactivated by SV40T in both genotypes. Use of the AR degradation enhancer ASC-J9 led to suppression of bladder tumorigenesis, with few adverse effects in the BBN-induced BCa mouse model. Together, these results provide the first direct in vivo evidence that Uro-AR has an important role in promoting bladder tumorigenesis and BCa progression. Targeting AR with ASC-J9 may provide a novel approach to suppress BCa initiation."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2013.01.018"xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Miyamoto H."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Hsu J.W."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Liang L."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Wu X.R."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Shyr C.R."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/author | "Hsu I."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/pages | "1811-1820"xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/title | "Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor."xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/23499463 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23499463 |
| http://purl.uniprot.org/citations/23499463 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23499463 |
| http://purl.uniprot.org/uniprot/#_P19091-mappedCitation-23499463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23499463 |
| http://purl.uniprot.org/uniprot/P19091 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23499463 |