| http://purl.uniprot.org/citations/23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23504993 | http://www.w3.org/2000/01/rdf-schema#comment | "NF-κB has been recognized as one of the factors responsible for the development of cancer; however, the mechanism by which high expression of NF-κB contributes to the progression of human oesophageal squamous cell cancer (ESCC) is not fully understood. In our investigations, NF-κBP65 was overexpressed in human ESCC tissues, especially in ESCC tissues with deep invasion and lymph node metastasis. Suppression of NF-κBP65 by siRNA decreased the invasion and proliferation ability of EC9706 cells in vitro. Furthermore, siRNA-mediated NF-κBP65 knock-down could lead to the downregulation of MMP-9, a metastasis-related gene. Reduced E-cadherin is a hallmark of invasive carcinomas that have acquired epithelial-mesenchymal transition (EMT) phenotypes and Vimentin is another molecule that is used widely as a marker of the EMT. We found upregulation of E-cadherin expression and downregulation of Vimentin was induced by NF-κBP65 siRNA, which suggests that NF-κBP65 siRNA could inhibit the invasion and proliferation ability of ECSS through attenuating the expression of MMP-9 and EMT. Thus, ESCC NF-κBP65 could be a useful target for cancer prevention and therapy."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10089"xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/author | "He W."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/author | "Fan Q."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/author | "Fanghui P."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/pages | "780-788"xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/title | "NF-kappaBP65 promotes invasion and metastasis of oesophageal squamous cell cancer by regulating matrix metalloproteinase-9 and epithelial-to-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/23504993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23504993 |
| http://purl.uniprot.org/citations/23504993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23504993 |
| http://purl.uniprot.org/uniprot/#_A0A087X0W8-mappedCitation-23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23504993 |
| http://purl.uniprot.org/uniprot/#_B7Z7V0-mappedCitation-23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23504993 |
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| http://purl.uniprot.org/uniprot/#_F2YBS6-mappedCitation-23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23504993 |
| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23504993 |
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| http://purl.uniprot.org/uniprot/#_Q9Y354-mappedCitation-23504993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23504993 |