| http://purl.uniprot.org/citations/23505387 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23505387 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment. Its vertebrate ortholog ZASP/Cypher also localizes to Z-discs, interacts with α-actinin through its PDZ domain, and is involved in Z-disc maintenance. Human mutations in ZASP cause myopathies and cardiomyopathies. Here we show that Drosophila Zasp52 is one of the earliest markers of Z-disc assembly, and we use a Zasp52-GFP fusion to document myofibril assembly by live imaging. We demonstrate that Zasp52 is required for adult Z-disc stability and pupal myofibril assembly. In addition, we show that two closely related proteins, Zasp66 and the newly identified Zasp67, are also required for adult Z-disc stability and are participating with Zasp52 in Z-disc assembly resulting in more severe, synergistic myofibril defects in double mutants. Zasp52 and Zasp66 directly bind to α-actinin, and they can also form a ternary complex. Our results indicate that Alp/Enigma family members cooperate in Z-disc assembly and myofibril formation; and we propose, based on sequence analysis, a novel class of PDZ domain likely involved in α-actinin binding."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003342"xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/author | "Katzemich A."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/author | "Schock F."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/author | "Czerniecki S."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/author | "Liao K.A."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/pages | "e1003342"xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/title | "Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly."xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/23505387 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23505387 |
| http://purl.uniprot.org/citations/23505387 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23505387 |
| http://purl.uniprot.org/uniprot/A1ZA47#attribution-19A5CFC6517006B2EF6A3B7D7097E816 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/A1ZA47#attribution-316298B7469A5AE63259A28C63557270 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q058U1#attribution-19A5CFC6517006B2EF6A3B7D7097E816 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q058U1#attribution-316298B7469A5AE63259A28C63557270 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q058U1#attribution-E4210A1FB4AA126510FBADEE9FDD88B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q95TZ7#attribution-19A5CFC6517006B2EF6A3B7D7097E816 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q95TZ7#attribution-316298B7469A5AE63259A28C63557270 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/Q95TZ7#attribution-E4210A1FB4AA126510FBADEE9FDD88B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/E1JI73#attribution-19A5CFC6517006B2EF6A3B7D7097E816 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/E1JI73#attribution-316298B7469A5AE63259A28C63557270 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |
| http://purl.uniprot.org/uniprot/E1JI73#attribution-E4210A1FB4AA126510FBADEE9FDD88B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23505387 |