| http://purl.uniprot.org/citations/23507046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23507046 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report, mutual effect of α-synuclein and GPX-1 is investigated to unveil their involvement in the PD pathogenesis in terms of cellular defense mechanism against oxidative stress. Biochemical and immunocytochemical studies showed that α-synuclein enhanced the GPX-1 activity with Kd of 17.3nM and the enzyme in turn markedly enhanced in vitro fibrillation of α-synuclein. Transmission electron microscopy revealed the fibrillar meshwork of α-synuclein containing GPX-1 located in locally concentrated islets. The entrapped enzyme was demonstrated to be protected in a latent form and its activity was fully recovered as released from the matrix. Therefore, novel defensive roles of α-synuclein and its amyloid fibrils against oxidative stress are suggested as the GPX-1 stimulator and the active depot for the enzyme, respectively."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbapap.2013.03.008"xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/author | "Koo H.J."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/author | "Paik S.R."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/author | "Yang J.E."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/pages | "972-976"xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/title | "alpha-Synuclein-mediated defense against oxidative stress via modulation of glutathione peroxidase."xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://purl.uniprot.org/core/volume | "1834"xsd:string |
| http://purl.uniprot.org/citations/23507046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23507046 |
| http://purl.uniprot.org/citations/23507046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23507046 |
| http://purl.uniprot.org/uniprot/P00435#attribution-312A396BCEDDA014B21EF8C08E57CE75 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23507046 |
| http://purl.uniprot.org/uniprot/P37840#attribution-312A396BCEDDA014B21EF8C08E57CE75 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23507046 |
| http://purl.uniprot.org/uniprot/P37840#attribution-9CCA2137F47CC9BCD932FCFBE712BD04 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23507046 |