| http://purl.uniprot.org/citations/23509069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23509069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23509069 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules, thereby generating pushing/pulling forces at the cell cortex. However, the molecular link between these two structures remains elusive. Here we describe a previously uncharacterized protein, MISP (C19orf21), as a substrate of Plk1 that is required for correct mitotic spindle positioning. MISP is an actin-associated protein throughout the cell cycle. MISP depletion led to an impaired metaphase-to-anaphase transition, which depended on phosphorylation by Plk1. Loss of MISP induced mitotic defects including spindle misorientation accompanied by shortened astral microtubules. Furthermore, we find that MISP formed a complex with and regulated the cortical distribution of the +TIP binding protein p150(glued), a subunit of the dynein-dynactin complex. We propose that Plk1 phosphorylates MISP, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201207050"xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201207050"xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Ponting C.P."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Ponting C.P."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Sanchez-Pulido L."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Sanchez-Pulido L."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Settele F."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Settele F."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Hoffmann I."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Hoffmann I."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Goenczy P."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Goenczy P."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Kotak S."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Kotak S."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Ehret L."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/author | "Ehret L."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/23509069 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |