| http://purl.uniprot.org/citations/23509692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23509692 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs, miRs) have the potential to control stem cells fate decisions. The cardiac- and skeletal-muscle-specific miRNA, miR-1, can regulate embryonic stem cells differentiation to cardiac lineage by suppressing gene expression of alternative lineages. Accordingly, we hypothesized that overexpression of miR-1 may also promote cardiac gene expression in mesenchymal stem cells. Since Notch signaling could inhibit muscle differentiation, a process in contrast with the effect of miR-1, miR-1-mediated repression of Notch signaling may contribute to the observed effects of miR-1 in mesenchymal stem cells. Thus, mesenchymal stem cells were infected by lentiviral vectors carrying miR-1, and cells expressing miR-1 were selected. Alterations in Notch signaling and cardiomyocyte markers, Nkx2.5, GATA-4, cTnT, and CX43, were identified by Western blot in the infected cells on days 1, 7, and 14. Our study showed that the downstream target molecule of Notch pathway, Hes-1, was obviously decreased in mesenchymal stem cells modified with miR-1, and overexpression of miR-1 promotes the specific cardiac gene expression in the infected cells. Knockdown of Hes-1 leads to the same effects on cell lineage decisions. Our results indicated that miR-1 promotes the differentiation of MSCs into cardiac lineage in part due to negative regulation of Hes-1."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.org/dc/terms/identifier | "doi:10.1155/2013/216286"xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Tang L."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Hu X.Q."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Pan J.Y."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Zhou S.H."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/author | "Fang Z.F."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/pages | "216286"xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/title | "miR-1-mediated induction of cardiogenesis in mesenchymal stem cells via downregulation of Hes-1."xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://purl.uniprot.org/core/volume | "2013"xsd:string |
| http://purl.uniprot.org/citations/23509692 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23509692 |
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